Intracellularly degradable hydrogen-bonded polymer capsules

K Kempe; SL Ng; ST Gunawan; KF Noi; F Caruso

Journal article

Intracellularly degradable hydrogen-bonded polymer capsules

K Kempe, SL Ng, ST Gunawan, KF Noi, F Caruso

Advanced Functional Materials | Published : 2014

DOI: 10.1002/adfm.201401397

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Abstract

The assembly of low-fouling polymer capsules with redox-responsive behavior and intracellular degradability is reported. Thiol-containing poly(2- ethyl-2-oxazoline) (PEtOxMASH) brushes are synthesized by atom transfer radical polymerization (ATRP) of oligo(2-ethyl-2-oxazoline)methacrylate and glycidyl methacrylate (GMA) and subsequent ring-opening reaction of the GMA. Sequential deposition of PEtOxMA SH /poly(methacrylic acid) (PMA) multilayers onto silica (SiO2) particle templates and crosslinking through disulfide formation yield stable capsules after the removal of the SiO2 templates by buffered hydrofl uoric acid (HF). The redox-responsive nature of the disulfide crosslinking groups enab..

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University of Melbourne Researchers

Frank Caruso Author

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Funding Acknowledgements

K.K. is grateful to the Alexander von Humboldt Foundation (Feodor-Lynen fellowship) for financial support. F. C. acknowledges the Australian Research Council for funding under the Australian Laureate Fellowship scheme (FL1201100030). Marta Redrado Notivoli (Nanomaterials Characterisation Node of the Materials Characterisation and Fabrication Platform, The University of Melbourne) is thanked for assistance with the AFM measurements.